1998 Conference

2nd International Phytochemical Conference Phytochemicals: A New Health Paradigm November 16 & 17, 1998

Epidemiological evidence has consistently provided positive correlation that diets rich in fruits, vegetables, and whole grains are associated with disease prevention. Through the chemical assessment of food groups, it has become apparent that health benefits do not correlate solely with nutrient content. In fact, many identified phytochemicals are associated with decreased incidences of certain disease states. Further evaluation of the mechanisms of action for optimal health will discern which phytochemicals and nutrients are effective at low concentrations within the existing food supply. This conference will include research presentations on the antimutagenic/anticarcinogenic effects of tea, isoflavones, garlic, the Cruciferae family, carotenoids, and curcumin. Phytomicrobials and bioactive components of alfalfa, rice bran oil, and saw palmetto will be reviewed, along with the use of phytochemicals to optimize gastrointestinal tract health. Strategies to identify bioactive phytochemicals and clinical trial design of test foods and/or phytochemicals are featured topics. A closing presentation will incorporate the basic principles of food science and technology essential to functional food development. These formulations of foods may deliver bioactive phytochemicals at levels that are equal to - or better than - the original source and directed toward optimal health promotion.

Welcome

Debra Jahner, MS Rehnborg Center for Nutrition and Wellness Buena Park, California

Introduction

Wayne B. Bidlack, Ph.D. Dean, College of Agriculture California State Polytechnic University, Pomona Pomona, California

Session I: Chemoprevention The Protective Effect of Tea on Cancer: Human Evidence Junshi Chen, Ph.D. Chinese Academy of Preventive Medicine Beijing, China Isoflavones: Genestein Effects on Growth of Human Breast Cancer Cells In Vivo and In Vitro William Helferich, Ph.D. University of Illinois Urbana, Illinois Phytochemical Effects on Carcinogen Metabolism Stephen S. Hecht, Ph.D. University of Minnesota Minneapolis, Minnesota Carotenoids and Curcumins N. Nishino, M.D., Ph.D. Kyoto Prefectural University of Medicine Kyoto, Japan QSAR and Molecular Modeling of Bioactive Phyto-Phenolic Compounds Eric J. Lien, Ph.D., Shijun Ren and Rubin Wang University of Southern California, School of Pharmacy Los Angeles, California Session II: Screening for Bioactivity Alfalfa Saponins: Chemistry and Application Wieslaw Oleszek, Ph.D. Institute of Soil Science and Plant Cultivation Pulaway, Poland Garlic: Effective Lowering of Serum Cholesterol Christopher Gardner, Ph.D. Stanford Center for Research in Disease Prevention Palo Alto, California Bioactive in Rice Bran and Rice Bran Oil Gary Miller and Rukmini Cheruvansky, Ph.D. Rice X Company El Dorado Hills, California Saw Palmetto: Critical Review, Chemistry and Application Paul Bubrick, Ph.D, and Kerry Stonebrook, MS Rehnborg Center for Nutrition and Wellness Buena Park, California Prebiotic Phytochemicals for Managing Intestine Ecosystems Randal K. Buddington, Ph.D. Mississippi State University Mississippi State, Mississippi Session III: Developing Novel Applications Strategies for Discovery of Bioactive Phytochemicals Stephen Duke, Ph.D. Natural Products Utilization Research Unit, USDA-ARS University, Mississippi Design of Clinical Trials to Test Bioactivity Kevin Maki, Ph.D. Chicago Center for Clinical Research Chicago, Illinois Antimicrobial Phytochemicals Narain Naidu, Ph.D. California State Polytechnic University Pomona, California Phytochemicals: Designing Bioactive Functional Foods Wayne R. Bidlack, Ph.D. California State Polytechnic University Pomona, California